ODCs

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Familial thrombocytosis

4 OMIM references -
3 associated genes
26 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3

Budd-Chiari syndrome

1 OMIM reference -
2 associated genes
20 signs/symptoms

Familial thrombocytosis

Budd-Chiari syndrome

JAK2	(UniProt - OMIM)	F5	(UniProt - OMIM)
MPL	(UniProt - OMIM)	JAK2	(UniProt - OMIM)
THPO	(UniProt - OMIM)


COMMON GENES	JAK2


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MPL	(0.66)	JAK2

Citations in the biomedical literature:

Familial thrombocytosis		Budd-Chiari syndrome
	Synonym(s): - Familial thrombocythemia - Hereditary thrombocythemia		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare hepatic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Diseases of the circulatory system -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: variable Average age of death: any age Type of inheritance: multigenic/multifactorial

	External references: 4 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: D006502


COMMON SIGNS	- Acute ischemic syndrome - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration

Familial thrombocytosis		Budd-Chiari syndrome
	Very frequent - Arterial embolism / thrombosis - Autosomal dominant inheritance - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Platelet disorders / thrombopathies - Platelets shape anomalies - Venous thrombosis / phlebitis / thrombophlebitis Frequent - Acute ischemia of the lower limbs - Facial pain / cephalalgia / migraine - Hyperhidrosis / increased sweating - Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness - Pruritus / itching - Thoracic / chest pain - Transient cerebral ischemia / stroke Occasional - Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim - Acute leukemia - Dizziness - Early death / lethality - Elocution disorders / dysarthria / dysphonia - Myelodysplastic syndrome - Myeloproliferative syndrome / chronic leukemia - Pulmonary hypertension - Seizures / epilepsy / absences / spasms / status epilepticus - Spontaneous abortions		Very frequent - Ascitis - Portal hypertension Frequent - Abnormal hepatic enzymes / transaminases - Acute abdominal pain / colic - Cirrhosis - Esophageal varices - Fever / chilling - Hepatocellular liver disease / hepatic failure - Hepatomegaly / liver enlargement (excluding storage disease) Occasional - Acute hepatic failure - Biliary / gallbladder stones / lithiasis / cholecystitis - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Hepatitis / icterus / cholestasis - Intestinal obstruction / ileus - Malabsorption / chronic diarrhea / steatorrhea - Mesenteric / intestinal infarction - Peritonitis / peritoneal abscess